Medicinal Utility of Thiosemicarbazones with Special Reference to Mixed Ligand and Mixed Metal Complexes: A Review

Thiosemicarbazone complexes possess structural diversity and variable bonding patterns potential biological implications ion sensing abilities. The ability of the transition metals to acquire different geometries like octahedral, square planar tetrahedral in coordination environments has encouraged researchers explore chemistry thiosemicarbazone which can also vary upon changing aldehydes ketones, substituents attached carbonyl moiety, metal its oxidation state, geometries, counter ions, presence a solvent or additional molecules structures on S N(4)-atoms. This review aims summarize recent developments synthesis medicinal importance ligands particular emphasis their complexes. mixed ligand-metal have an important role play systems because number try combine with same ions vivo. Different activities producing synergetic results enhancing potency formed complex. They storage transport substances, therefore article covers ligand thiosemicarbazones hetero 1,10-phenanthroline, pyridine, triphenyl phosphine etc. mechanistic action benefits years. binuclear two been explored here. Dinuclear shown interesting most cases, such containing metal–metal bond affects complex’s magnetic properties as well. It well discussed course this study that show enhanced activity than free ion. studies cited sourced from publications indexed known databases. Some recently alterations paper future substituted may emerge multi-target inhibitors.